Satoshi Ishii, Takayuki Fujiwara, Hiroki Yagi, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Ryo Inuzuka, Yuki Taniguchi, Masaru Hatano, Issei Komuro. A novel pathogenic variant located just upstream of the C-terminal Ser423-X-Ser425 phosphorylation motif in SMAD3 causing Loeys-Dietz syndrome. Mol Genet Genomic Med. 2023 Oct 20:e2257.
Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Manami Katoh, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Tomonobu Yanase, Yoshiaki Kubota, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Satoshi Nishimura, Issei Komuro. PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice. JCI insight. 2023 Sep 8;8(17):e162632.
Satoshi Ishii, Shun Minatsuki, Masaru Hatano, Akihito Saito, Hiroki Yagi, Mai Shimbo, Katsura Soma, Takayuki Fujiwara, Hidetaka Itoh, Chihiro Konoeda, Masaaki Sato, Norifumi Takeda, Masao Daimon, Jun Nakajima, Issei Komuro. The ratio of TAPSE to PASP predicts prognosis in lung transplant candidates with pulmonary arterial hypertension. Sci Rep. 2023 Mar 7;13(1):3758.
Satoshi Ishii, Masaru Hatano, Hisataka Maki, Shun Minatsuki, Akihito Saito, Hiroki Yagi, Mai Shimbo, Katsura Soma, Genri Numata, Takayuki Fujiwara, Norifumi Takeda, Issei Komuro. Prognostic value of follow-up vasoreactivity test in pulmonary arterial hypertension. J Cardiol. 2023 Jan 20;S0914-5087(23)00005-9.
Yagi H, Takeda N, Amiya E, Akiyama N, Chang H, Ishiura H, Sato J, Akazawa H, Morita H and Komuro I. Nonsyndromic arteriopathy and aortopathy and vascular Ehlers-Danlos syndrome causing COL3A1 variants. Am J Med Genet A. 2022;188:2777-2782.
Suzuki Y, Kaneko H, Yano Y, Okada A, Itoh H, Ueno K, Matsuoka S, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Yokota I, Node K, Yasunaga H and Komuro I. Dose-dependent relationship of blood pressure and glycemic status with risk of aortic dissection and aneurysm. Eur J Prev Cardiol. 2022.
Sayama S, Iriyama T, Takeda N, Yamauchi H, Toshimitsu M, Seyama T, Sone K, Kumasawa K, Nagamatsu T, Fujii T and Osuga Y. Proposed Management Policy for Pregnant Women with Loeys-Dietz Syndrome Following Prophylactic Aortic Root Replacement Based on Experience from a Tertiary Care Center. Int Heart J. 2022;63:176-179.
Goto K, Minatsuki S, Fujita K, Takeda N, Hatano M and Komuro I. Two Siblings With Peripheral Pulmonary Arterial Stenosis: Pulmonary Angiography of Advanced and Early Stages. Chest. 2022;161:e75-e80.
Taniguchi Y, Takeda N, Inuzuka R, Matsubayashi Y, Kato S, Doi T, Yagi H, Yamauchi H, Ando M, Oshima Y and Tanaka S. Impact of pathogenic FBN1 variant types on the development of severe scoliosis in patients with Marfan syndrome. J Med Genet. 2021.
Taniguchi Y, Matsubayashi Y, Kato S, Doi T, Takeda N, Yagi H, Inuzuka R, Oshima Y and Tanaka S. Predictive Physical Manifestations for Progression of Scoliosis in Marfan Syndrome. Spine (Phila Pa 1976). 2021;46:1020-1025.
Takeda N, Inuzuka R, Yagi H, Morita H, Ando M, Yamauchi H, Taniguchi Y, Porto KJ, Kanaya T, Ishiura H, Mitsui J, Tsuji S, Toda T, Ono M and Komuro I. Clinical Impact of Copy Number Variation on the Genetic Diagnosis of Syndromic Aortopathies. Circ Genom Precis Med. 2021;14:e003458.
Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Maemura S, Suzuki T, Takiguchi H, Kubota Y, Seo K, Sakata A, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Nishimura S and Komuro I. Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice. Circulation. 2021;144:1452-1455.
Hara H, Maemura S, Fujiwara T, Takeda N, Ishii S, Yagi H, Suzuki T, Harada M, Toko H, Kanaya T, Ijichi H, Moses HL, Takimoto E, Morita H, Akazawa H and Komuro I. Inhibition of transforming growth factor-beta signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome. PLoS One. 2020;15:e0239908.
Takeda N and Komuro I. Genetic basis of hereditary thoracic aortic aneurysms and dissections. J Cardiol. 2019;74:136-143.
Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H and Komuro I. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019;128:90-95.
Fujiwara T, Takeda N, Ishii S, Morita H and Komuro I. Unique Mechanism by Which TGFBR1 Variants Cause 2 Distinct System Diseases- Loeys-Dietz Syndrome and Multiple Self-Healing Squamous Epithelioma. Circ Rep. 2019;1:487-492.
Takeda N, Inuzuka R, Maemura S, Morita H, Nawata K, Fujita D, Taniguchi Y, Yamauchi H, Yagi H, Kato M, Nishimura H, Hirata Y, Ikeda Y, Kumagai H, Amiya E, Hara H, Fujiwara T, Akazawa H, Suzuki JI, Imai Y, Nagai R, Takamoto S, Hirata Y, Ono M and Komuro I. Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome. Circ Genom Precis Med. 2018;11:e002058.
Takeda N, Hara H, Fujiwara T, Kanaya T, Maemura S and Komuro I. TGF-beta Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections. Int J Mol Sci. 2018;19.
Sayama S, Takeda N, Iriyama T, Inuzuka R, Maemura S, Fujita D, Yamauchi H, Nawata K, Bougaki M, Hyodo H, Shitara R, Nakayama T, Komatsu A, Nagamatsu T, Osuga Y and Fujii T. Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study. BJOG. 2018;125:487-493.
Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M and Komuro I. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury. JACC Basic to translational science. 2018;3:639-653.
Fujiwara T, Takeda N, Hara H, Morita H, Kishihara J, Inuzuka R, Yagi H, Maemura S, Toko H, Harada M, Ikeda Y, Kumagai H, Nomura S, Takimoto E, Akazawa H, Ako J and Komuro I. Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys-Dietz syndrome or multiple self-healing squamous epithelioma. Eur J Hum Genet. 2018;26:1151-1158.
Hara H, Takeda N and Komuro I. Pathophysiology and therapeutic potential of cardiac fibrosis. Inflamm Regen. 2017;37:13.
Takeda N, Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H and Komuro I. Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys-Dietz Syndromes. Int Heart J. 2016;57:271-7.
Takeda N, Morita H, Fujita D, Inuzuka R, Taniguchi Y, Imai Y, Hirata Y and Komuro I. Congenital contractural arachnodactyly complicated with aortic dilatation and dissection: Case report and review of literature. Am J Med Genet A. 2015;167A:2382-7.
Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA and Epstein JA. Hopx distinguishes hippocampal from lateral ventricle neural stem cells. Stem Cell Res. 2015;15:522-529.
Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BLM and Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 2015;6:6727.
Imai Y, Morita H, Takeda N, Miya F, Hyodo H, Fujita D, Tajima T, Tsunoda T, Nagai R, Kubo M and Komuro I. A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees. Int J Cardiol. 2015;195:290-2.
Fujita D, Takeda N, Morita H, Kato M, Nishimura H, Inuzuka R, Taniguchi Y, Nawata K, Hyodo H, Imai Y, Hirata Y and Komuro I. A novel mutation of TGFBR2 causing Loeys-Dietz syndrome complicated with pregnancy-related fatal cervical arterial dissections. Int J Cardiol. 2015;201:288-90.
Fujita D, Takeda N, Imai Y, Inuzuka R, Komuro I and Hirata Y. Pathophysiology and Japanese clinical characteristics in Marfan syndrome. Pediatr Int. 2014;56:484-91.
Takeda N, Jain R, Li D, Li L, Lu MM and Epstein JA. Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury. PLoS One. 2013;8:e66314.
Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE and Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development. 2013;140:1655-64.
Ogawa N, Imai Y, Nishimura H, Kato M, Takeda N, Nawata K, Taketani T, Morota T, Takamoto S, Nagai R and Hirata Y. Circulating transforming growth factor beta-1 level in Japanese patients with Marfan syndrome. Int Heart J. 2013;54:23-6.
Takeda N and Manabe I. Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling. International journal of inflammation. 2011;2011:535241.
Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM and Epstein JA. Interconversion between intestinal stem cell populations in distinct niches. Science. 2011;334:1420-4.
Ogawa N, Imai Y, Takahashi Y, Nawata K, Hara K, Nishimura H, Kato M, Takeda N, Kohro T, Morita H, Taketani T, Morota T, Yamazaki T, Goto J, Tsuji S, Takamoto S, Nagai R and Hirata Y. Evaluating Japanese patients with the Marfan syndrome using high-throughput microarray-based mutational analysis of fibrillin-1 gene. Am J Cardiol. 2011;108:1801-7.
Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ and Nagai R. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010;120:254-65.
