心不全チームの臨床研究

重症心不全に対するトルバプタンの効果

既存の利尿剤に抵抗性の重症うっ血性心不全に対する新規治療薬であるトルバプタンを用いた臨床研究を行っている。尿浸透圧を用いたレスポンダーの選別方法、尿浸透圧の推定方法の構築、レスポンダーとノンレスポンダーに対するトルバプタンの臨床効果の比較、血清ナトリウム値によるトルバプタンの臨床効果の比較などを研究している。また、トルバプタンの長期投与における有効性を多施設共同研究で評価している(AQUA-TLV study)。

移植前重症心不全に対する術前評価

補助人工心臓を用いた最適な治療戦略構築のために各種臨床研究を行っている。術前因子を用いて術後の生命予後、両心補助の必要性や術後臓器不全の改善を予測するスコアリングを構築したり、術後慢性右心不全やリバースリモデリングを予測したり、補助人工心臓からの離脱方法に関する研究を行っている。また肺高血症を合併する重症心不全に対する肺高血圧症治療薬を用いた治療戦略の研究も行っている。

心臓移植後の拒絶反応に対する予防・治療

心臓移植術後の管理としてエベロリムスを加えた免疫抑制剤を用いた治療戦略において、腎機能や移植後冠動脈病変に対する有効性に関して研究している。細胞性拒絶だけでなく液性拒絶の予防・診断・治療法に関しても研究している。

発表論文

Nitta Daisuke, Kinugawa Koihciro, Imamura Teruhiko, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Amiya Eisuke, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. A Novel Scoring System Predicts Ineligibility for Bridge to Implantable Left Ventricular Assist Device as Destination Therapy before Extracorporeal Ventricular Assist Device Implantation For The Coming Era of Destination Therapy in Japan. Circ J. In Press.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Kinoshita Osamu, Nawaata Kan, Ono Minoru. Everolimus Attenuates Myocardial Hypertrophy and Improves Diastolic Function in Heart Transplant Recipients. Int Heart J. In Press

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Development of Aortic Insufficiency among Those with Closed Aortic Valve at Rest during Ventricular Assist Device Treatment. Int Heart J. In Press

Imamura Teruhiko, Kinugawa Koichrio. Preoperative Prediction of Aortic Insufficiency during Ventricular Assist Device Treatment. Int Heart J. In Press.

Imamura Teruhiko, Kinugawa Koichiro. Centrifugal Pump EVAHEART prevents Development of Aortic Insufficiency Preserving Pulse Pressure. Int Heart J. In Press.

Imamura Teruhiko, Kinugawa Koihciro, Komuro Issei. Tolvaptan Prolongs Blockage of the Vasopressin Type II Receptor over 24 Hours in Responders with Stage D Heart Failure. Int Heart J. In Press

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisule, Komuro Issei. Long-Term Adaptive Servo-Ventilator Treatment Prevents Cardiac Death and Improves Clinical Outcome. Int Heart J. In Press

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Komuro Issei. Shorter Heart Failure Duration is a Predictor of Left Ventricular Reverse Remodeling during Adaptive Servo-Ventilator Treatment in Patients with Advanced Heart Failure. Int Heart J. In Press

Imamura Teruhiko, Kinugawa Koichiro. Mid-term Administration of Tolvaptan Improves Renal Function Accompanied by Dose-reduction in Furosemide in Aquaporin-defined Responders. Int Heart J. 2015 Nov 9. PMID 26549392.

Imamura Teruhiko, Kinugawa Koichiro, Kinoshita Osamu, Nawata Kan, Ono Minoru. High pulmonary vascular resistance in addition to low right ventricular stroke volume index effectively predicts biventricular assist device requirement. J Artif Organs. 2015 Sep 22. PMID 26395777.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Komuro Issei. Complete Left Bundle Branch Block and Smaller Left Atrium Are Predictors of Response to Cardiac Resynchronization Therapy in Advanced Heart Failure. Circ J. 2015;79(11)2141-21.

Hasumi Emiko, Fujiu Katsutoshi, Imamura Teruhiko, Iwata Hiroshi, Sawaki Daigo, Hosoya Yumiko, Ando Jiro, Kojima Toshiya, Shimuzu Yu, Oguri Gaku, Matsubara Takumi, Hatano Masaru, Akazawa Hiroshi, Watanabe Masafumi, Ono Minoru, Komuro Issei. Cardiac Arrest Triggered by Subepical Aneurysm Without Cardiac Rupture. Ciarc J. 2015 Oct 27. PMID 26511228.

Imamura Teruhiko, Kinugawa Koichiro. Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration. Int Heart J. 2015;56(5):568-70.

Imamura Teruhiko, Kinugawa Koichiro, Sakata Yasushi, Miyagawa S, Sawa Y, Yamazaki K, Ono Minoru. Improved clinical course of autologous skeletal myoblast sheet (TCD-51073) transplantation when compared to a propensity score-matched cardiac resynchronization therapy population. J Artif Organs. 2015 Aug 13. PMID 26267666.

Nitta Daisuke, Kinugawa Koichiro, Imamura Teruhiko, Endo Miyoko, Amiya Eisuke, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Komuro Issei. An Experience of Landiolol Use for an Advanced Heart Failure Patient With Severe Hypotension. Int Heart J. 2015;56(5):564-7.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Kinoshita Osamu, Nawata Kan, Ono Minoru. Preoperative iodine-123 meta-iodobenzylguanidine imaging is a novel predictor of left ventricular reverse remodeling during treatment with a left ventricular assist device. J Artif Organs. 2015 Jul 29. PMID 26219410.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Ono Minoru. Advantage of Pulsatility in Left Ventricular Reverse Remodeling and Aortic Insufficiency Prevention During Left Ventricular Assist Device Treatment. Circ J. 2015;79(9):1994-9.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Ono Minoru. Perioperative Hypoalbuminemia Affects Improvement in Exercise Tolerance After Left Ventricular Assist Device Implantation. Circ J. 2015;79(9):1970-5.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Prophylactic Intra-Aortic Balloon Pump Before Ventricular Assist Device Implantation Reduces Perioperative Medical Expenses and Improves Postoperative Clinical Course in INTERMACS Profile 2 Patients. Circ J. 2015;79(9):1963-9.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Ono Minoru. Opening of Aortic Valve during Exercise is Key to Preventing Development of Aortic Insufficiency during Ventricular Assist Device Treatment. ASAIO J. 2015;61(5):514-9.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Komuro Issei. Should Cardiac Resynchronization Therapy be a Rescue Therapy for Inotrope-Dependent Patients with Advanced Heart Failure? J Card Fail. 2015:21(6):535-8.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Opening of Native Aortic Valve Accompanied After Left Ventricular Assist Device Implantation in Patients With Insufficient Preoperative Beta-Blocker Treatment. Int Heart J. 2015;56(3):303-8.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Ono Minoru. Biventricular failure with low pulmonary vascular resistance was managed by left ventricular assist device alone without right-sided mechanical support. J Artif Organs. 2015;18(3):272-5.

Ko T, Hatano Masaru, Nitta Daisuke, Muraoka Hironori, Minatsuki Shun, Imamura Teruhiko, Inaba Toshiro, Maki Hisataka, Yao Atsushi, Kinugawa Koichiro, Komuro Issei. A case of interferon-α-induced pulmonary arterial hypertension after living donor liver transplantation. Heart Vessels. 2015 Jun 17.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Novel scoring system using postoperative cardiopulmonary exercise testing predicts future explantation of left ventricular assist device. Circ J. 2015;79(3):560-6.

Imamura Teruhiko, Kinugawa Koichiro, Doi Kent, Hatano Masaru, Fujino Takeo, Kinoshita Osamu, Nawata Kan, Noiri E, Kyo Shunei, Ono Minoru. Plasma Neutrophil Gelatinase-Associated Lipocalin and Worsening Renal Function during Everolimus Therapy after Heart Transplantation. Int Heart J. 201;56(1):73-9.

Nitta Daisuke, Kinugawa Koichiro, Imamura Teruhiko, Hatano Masaru, Ono Minoru, Nakamura Fumihiko, Kurokawa Mineo, Komuro Issei. How Should We Treat Early-Post Transplant Lymphoproliferative Disease After Heart Transplantation? Int Heart J. 2015 Nov 6. PMID 26549285.

Kimura Mitsutoshi, Nawata Kan, Kinoshita Osamu, Hatano Masaru, Imamura Teruhiko, Kinugawa Koichiro, Ono Minoru. Successful Treatment of Intractable Fluid Retention Using Tolvaptan After Treatment for Postoperative Mediastinitis in a Patient With a Left Ventricular Assist Device. Int Heart J. 2015;56(5):574-7.

Fujino Takeo, Kinugawa Koichiro, Nitta Daisuke, Imamura Teruhiko, Maki Hisataka, Amiya Eisuke, Hatano Masaru, Kimura Mitsutoshi, Kinoshita Osamu, Nawata Kan, Komuro Issei, Ono Minoru. Donor age is a predictor of early low output after heart transplantation. J Cardiol. 2015 Aug 10.

Kato NaokoP, Okada Ikuko, Imamura Teruhiko, Kagami Yukie, Endo Miyoko, Nitta Daisuke, Fujino Takeo, Muraoka Hironori, Minatsuki Shun, Maki Hisataka, Inaba Toshiro, Kinoshita Osamu, Nawata Kan, Hatano Masaru, Yao Atsushi, Kyo Shunei, Ono Minoru, Jaarsma T, Kinugawa Koichiro. Quality of Life and Influential Factors in Patients Implanted With a Left Ventricular Assist Device. Circ J. 2015 Aug 10.

Muraoka Hironori, Imamura Teruhiko, Hatano Masaru, Maki Hisataka, Yao Atsushi, Kinugawa Koichiro, Komuro Issei. Secure Combination Therapy with Low-dose Bosentan and Ambrisentan to Treat Portopulmonary Hypertension Minimizing Each Adverse Effects. Int Heart J. 2015:56(4):471-3.

Muraoka Hironori, Imamura Teruhiko, Kinugawa Koichiro. Reverse Remodeling Achieved by Combination Therapy with High-Dose Beta Blocker and Cardiac Resynchronization. Int Heart J 2015:56(4):462-5.

Minatsuki Shun, Miura I, Yao Atsushi, Abe Hiroshi, Muraoka Hironoriironori, Tanaka M, Imamura Teruhiko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinugawa Koichiro, Yao T, Fukayama M, Nagai Ryozo, Komuro Issei. Platelet-Derived Growth Factor Receptor-Tyrosine Kinase Inhibitor, Imatinib, Is Effective for Targeting Pulmonary Hypertension Induced by Pulmonary Tumor Thrombotic Microangiopathy. Int Heart J. 2015;56(2):245-8.

Fujino Takeo, Yao Atsushi, Hatano Masaru, Inaba Toshiro, Muraoka Hironori, Minatsuki Shunhun, Imamura Teruhiko, Maki Hisataka, Kinugawa Koichiro, Ono Minoru, Nagai Ryozo, Komuro Issei. Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and assocaited pulmonary arterial hypertension. Int Heart J. 2015;56(1):86-93.

Shimizu K, Doi Kent, Imamura Teruhiko, Noiri Eisei, Yahagi Naoki, Nangaku Masaomi, Kinugawa Koichiro. Ratio of urine and blood urea nitrogen concentration predicts the response of tolvaptan in congestive heart failure. Nephrology. 2015;(6):405-12.

Kimura Mitsutoshi, Kinoshita Osamu, Nawata Kan, Nishimura Takashi, Hatano Masaru, Imamura Teruhiko, Endo Miyoko, Kagami Yukie, Kubo H, Kashiwa K, Kinugawa Koichiro, Kyo Shunei, Komuro Issei, Ono Minoru. Midterm outcome of implantable left ventricular assist devices as a bridge to transplantation: Single-center experience in Japan. J Cardiol. 2015;65(5):383-9.

Imamura Teruhiko, Kinugawa Koichiro, Okada Ikuko, Kato Naoko, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Parasympathetic Reinnervation Acompanied by Improved Post-Exercise Heart Rate Recovery and Quality of Life in Heart Transplant Recipients. Int Heart J. 2015;56(2):180-5.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Late Rejection Occurred in Recipients Who Experienced Acute Cellular Rejection Within the First Year After Heart Transplantation. Int Heart J. 2015;56(2):174-9.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Komuro Issei. Novel Scoring System using Cardiopulmonary Exercise Testing predict Prognosis in Heart Failure Patients Receiving Guideline-directed Medical Therapy. Circ J. 2015;79(5):1068-75.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Readmission due to driveline infection can be predicted by new score by using serum albumin and body mass index during long-term left ventricular assist device support. J Artif Organs. 2015 Jan 21.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Yao Atsushi, Kyo Shunei, Ono Minoru. Is the Internal Jugular Vein or Femoral Vein a Better Approach Site for Endo Miyokoyocardial Biopsy in Heart Transplant Recipients? Int Heart J. 2015;56(1):67-72.

Imamura Teruhiko, Kinugawa Koichiro, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru Aortic Insufficiency in Patients With Sustained Left Ventricular Systolic Dysfunction After Axial Flow Assist Device Implantation. Circ J. 2015;79(1):104-11.

Imamura Teruhiko, Kinugawa Koichiro, Nitta Daisuke, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Lower rotation speed stimulates sympathetic activation during continuous-flow left ventricular assist device treatment. J Artif Organs. 2015;18(1):20-6.

Imamura Teruhiko. Aquaporin-2-guided tolvaptan therapy in patients with congestive heart failure accompanied by chronic kidney disease. Int Heart J. 2014;55(6):482-3.

Imamura Teruhiko, Kinugawa Koichiro, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Recipients with shorter cardiopulmonary bypass time achieve improvement of parasympathetic reinnervation within 6 months after heart transplantation. Int Heart J. 2014;55(5):440-4.

Imamura Teruhiko, Kinugawa Koichiro, Hatano Masaru, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru, Komuro Issei. Low cardiac output stimulates vasopressin release in patients with stage d heart failure. Circ J. 2014;78(9):2259-67.

Imamura Teruhiko, Kinugawa Koichiro, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Komuro Issei. Increased Urine Aquaporin-2 Relative to Plasma Arginine Vasopressin Is a Novel Marker of Response to Tolvaptan in Patients With Decompensated Heart Failure. Circ J. 2014;78(9):2240-9.

Kato Naoko, Kinugawa Koichiro, Imamura Teruhiko, Muraoka Hironori, Maki Hisataka, Inaba Toshiro, Hatano Masaru, Yao Atsushi, Nagai Ryozo Differential impacts of achieved heart rate and achieved dose of β-blocker on clinical outcomes in heart failure with and without atrial fibrillation. Int J Cardiol. 2014;173(2):331-3.

Imamura Teruhiko, Kinugawa Koichiro, Ohtani Tomohiro, Sakata Yasushi, Higo Taiki, Kinugawa Shintaro, Tsutsui Hiroyuki, Sunagawa Kenji, Komuro Issei. Assessment of quality of life during long-term treatment of tolvaptan in refractory heart failure: design and rationale of the AQUA-TLV study. Int Heart J. 2014;55(3):264-7.

Fujino Takeo, Kinugawa Koichiro, Hatano Masaru, Imamura Teruhiko, Muraoka Hironori, Minatsuki Shun, Inaba Toshiro, Maki Hisataka, Kinoshita Osamu, Nawata Kan, Yao Atsushi, Ono Minoru, Komuro Issei. Low blood pressure, low serum cholesterol and anemia predict early necessity of ventricular assist device implantation in patients with advanced heart failure at the time of referral from non-ventricular assist device institutes. Circ J. 2014;78(12):2882-9.

Imamura Teruhiko, Kinugawa Koichiro, Hatano Masaru, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Kinoshita Osamu, Amiya Eisuke, Nawata Kan, Yao Atsushi, Kyo Shunei, Ono Minoru, Komuro Issei. Status 2 Patients Had Poor Prognosis Without Mechanical Circulatory Support. Circ J. 2014;78(6):1396-404.

Imamura Teruhiko, Kinugawa Koichiro, Murasawa T, Kagami Yukie, Endo Miyoko, Muraoka Hironori, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Komuro Issei, Ono Minoru. Cardiac allograft vasculopathy can be distinguished from donor-transmitted coronary atherosclerosis by optical coherence tomography imaging in a heart transplantation recipient. Int Heart J. 2014;55(2):178-80.

Imamura Teruhiko, Kinugawa Koichiro, Minatsuki Shun, Muraoka Hironori, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Komuro Issei. Urine sodium excretion after tolvaptan administration is dependent upon baseline serum sodium levels. Int Heart J. 2014;55(2):131-7.

Imamura Teruhiko, Kinugawa Koichiro, Kato Naoko, Muraoka Hironori, Fujino Takeo, Inaba Toshiro, Maki Hisataka, Kinoshita Osamu, Hatano Masaru, Kyo Shunei, Ono Minoru. Late-onset right ventricular failure in patients with preoperative small left ventricle after implantation of continuous flow left ventricular assist device. Circ J. 2014;78(3):625-33.

Imamura Teruhiko, Kinugawa Koichiro, Hatano Masaru, Fujino Takeo, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Kagami Yukie, Endo Miyoko, Kinoshita Osamu, Nawata Kan, Kyo Shunei, Ono Minoru. Preoperative beta-blocker treatment is a key for deciding left ventricular assist device implantation strategy as a bridge to recovery. J Artif Organs. 2014;17(1):23-32.

Kinugawa Koichiro, Imamura Teruhiko, Komuro Issei. Experience of a vasopressin receptor antagonist, tolvaptan, under the unique indication in Japanese heart failure patients. Clin Pharmacol Ther. 2013;94(4):449-51.

Imamura Teruhiko, Kinugawa Koichiro, Minatsuki Shun, Muraoka Hironori, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Komuro Issei. Tolvaptan can improve clinical course in responders. Int Heart J. 2013;54(6):377-81.

Imamura Teruhiko, Kinugawa Koichiro, Kato Naoko, Kagami Yukie, Endo Miyoko, Kaneko N, Minatsuki Shun, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Doi Kent, Yao Atsushi, Takazawa Y, Ono Minoru, Kyo Shunei, Komuro Issei. Successful treatment of hemodynamic compromise caused by antibody-mediated and cellular rejection in a recipient 12 years after heart transplantation. Int Heart J. 2013;54(5):328-31.

Imamura Teruhiko, Kinugawa Koichiro, Ono Minoru, Kagami Yukie, Endo Miyoko, Minatsuki Shun, Muraoka Hironori, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Kyo Shunei, Komuro Issei. Everolimus-incorporated immunosuppressant strategy improves renal dysfunction while maintaining low rejection rates after heart transplantation in Japanese patients. Int Heart J. 2013;54(4):222-7.

Imamura Teruhiko, Kinugawa Koichiro, Kato Naoko, Minatsuki Shun, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Shiga Taro, Hatano Masaru, Hosoya Y, Takahashi M, Yao Atsushi, Kyo Shunei, Ono Minoru, Komuro Issei. A case with recovery of response to tolvaptan associated with remission of acute kidney injury and increased urine osmolality. Int Heart J. 2013;54(2):115-8.

Kato Naoko, Kinugawa Koichiro, Nakayama E, Tsuji T, Kumagai Y, Imamura Teruhiko, Maki Hisataka, Shiga Taro, Hatano Masaru, Yao Atsushi, Miura C, Komuro Issei, Nagai Ryozo. Insufficient self-care is an independent risk factor for adverse clinical outcomes in Japanese patients with heart failure. Int Heart J. 2013;54(6):382-9.

Imamura Teruhiko, Kinugawa Koichiro, Hatano Masaru, Kato Naoko, Minatsuki Shun, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Kimura Mitsutoshi, Kinoshita Osamu, Shiga Taro, Yao Atsushi, Kyo Shunei, Ono Minoru, Komuro Issei. Acute pulmonary vasoreactivity test with sildenafil or nitric monoxide before left ventricular assist device implantation. J Artif Organs. 2013;16(3):389-92.

Imamura Teruhiko, Kinugawa Koichiro, Kato Naoko, Minatsuki Shun, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Shiga Taro, Hatano Masaru, Yao Atsushi, Kyo Shunei, Ono Minoru, Komuro Issei. Successful conversion from thiazide to tolvaptan in a patient with stage d heart failure and chronic kidney disease before heart transplantation. Int Heart J. 2013;54(1):48-50.

Imamura Teruhiko, Kinugawa Koichiro, Minatsuki Shun, Muraoka Hironori, Kato Naoko, Inaba Toshiro, Maki Hisataka, Shiga Taro, Hatano Masaru, Yao Atsushi, Kyo Shunei, Komuro Issei. Urine osmolality estimated using urine urea nitrogen, sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patients. Circ J. 2013;77(5):1208-13.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Kato Naoko, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Hirata Yasunobu, Nishimura Takashi, Kyo Shunei, Ono Minoru, Nagai Ryozo. Correction of hyponatremia by tolvaptan before left ventricular assist device implantation. Int Heart J. 2012;53(6):391-3.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Kato Naoko, Muraoka Hironori, Minatsuki Shun, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Kyo Shunei, Nagai Ryozo. Novel criteria of urine osmolality effectively predict response to tolvaptan in decompensated heart failure patients--association between non-responders and chronic kidney disease. Circ J. 2013;77(2):397-404.

Inaba Toshiro, Yao Atsushi, Nakao T, Hatano Masaru, Maki Hisataka, Imamura Teruhiko, Shiga Taro, Yamazaki T, Sonoda M, Kinugawa Koichiro, Shiota T, Suzuki J, Takenaka K, Hirata Yasunobu, Nagai Ryozo. Volumetric and functional assessment of ventricles in pulmonary hypertension on 3-dimensional echocardiography. Circ J. 2013;77(1):198-206.

Imamura Teruhiko, Kinugawa Koichiro, Hatano Masaru, Kato Naoko, Minatsuki Shun, Muraoka Hironori, Inaba Toshiro, Maki Hisataka, Shiga Taro, Yao Atsushi, Kyo Shunei, Ono Minoru, Nagai Ryozo. Bosentan improved persistent pulmonary hypertension in a case after implantation of a left ventricular assist device. J Artif Organs. 2013;16(1):101-4.

Kimura Mitsutoshi, Kinoshita Osamu, Nishimura Takashi, Imamura Teruhiko, Shiga Taro, Kashiwa K, Kinugawa Koichiro, Kyo Shunei, Ono Minoru. Successful weaning from the DuraHeart with a low left ventricular ejection fraction. J Artif Organs. 2013;16(4):504-7.

Kato Naoko, Kinugawa Koichiro, Imamura Teruhiko, Muraoka Hironori, Minatsuki Shun, Inaba Toshiro, Maki Hisataka, Shiga Taro, Hatano Masaru, Yao Atsushi, Komuro Issei, Nagai Ryozo. Trend of clinical outcome and surrogate markers during titration of β-blocker in heart failure patients with reduced ejection fraction: relevance of achieved heart rate and β-blocker dose. Circ J. 2013;77(4):1001-8.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Endo Miyoko, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Nishimura Takashi, Hirata Yasunobu, Kyo Shunei, Ono Minoru, Nagai Ryozo. Preoperative levels of bilirubin or creatinine adjusted by age can predict their reversibility after implantation of left ventricular assist device. Circ J. 2013;77(1):96-104.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Kato Naoko, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Hirata Yasunobu, Akahane M, Nishimura Takashi, Kyo Shunei, Ono Minoru, Nagai Ryozo. How to demonstrate the reversibility of end-organ function before implantation of left ventricular assist device in INTERMACS profile 2 patients J Artif Organs. 2012;15(4):395-8.

Imamura Teruhiko, Kinugawa Koichiro, Mohri D, Shiga Taro, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Isayama H, Yao Atsushi, Hirata Yasunobu, Koike K, Nagai Ryozo. A case of pancreatic cancer after heart transplantation. Int Heart J. 2012;53(3):205-7.

Imamura Teruhiko, Shiga Taro, Kinugawa Koichiro, Kato Naoko, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Hirata Yasunobu, Nagai Ryozo. Successful conversion to everolimus after cytomegalovirus infection in a heart transplant recipient. Int Heart J. 2012;53(3):199-201.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Endo Miyoko, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Nishimura Takashi, Hirata Yasunobu, Kyo Shunei, Ono Minoru, Nagai Ryozo. An elevated ratio of early to late diastolic filling velocity recovers after heart transplantation in a time-dependent manner. J Cardiol. 2012;60(4):295-300.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Endo Miyoko, Kato Naoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Nishimura Takashi, Hirata Yasunobu, Kyo Shunei, Ono Minoru, Nagai Ryozo. Novel risk scoring system with preoperative objective parameters gives a good prediction of 1-year mortality in patients with a left ventricular assist device. Circ J. 2012;76(8):1895-903.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Imai Y, Yao Atsushi, Hirata Yasunobu, Nishimura Takashi, Kyo Shunei, Ono Minoru, Nagai Ryozo. Early decision for a left ventricular assist device implantation is necessary for patients with modifier A. J Artif Organs. 2012;15(3):301-4.

Ishida J, Kinugawa Koichiro, Shiga Taro, Imamura Teruhiko, Hatano Masaru, Maki Hisataka, Inaba Toshiro, Yao Atsushi, Hirata Yasunobu, Nishimura Takashi, Kyo Shunei, Ono Minoru, Nagai Ryozo. Rapidly progressive cardiac allograft vasculopathy in early onset regressed with everolimus treatment in an adult cardiac recipient. Int Heart J. 2012;53(6):388-90.

Shiga Taro, Kinugawa Koichiro, Imamura Teruhiko, Kato Naoko, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Nishimura Takashi, Hirata Yasunobu, Kyo Shunei, Ono Minoru, Nagai Ryozo. Combination evaluation of preoperative risk indices predicts requirement of biventricular assist device. Circ J. 2012;76(12):2785-91.

Imamura Teruhiko, Kinugawa Koichiro, Shiga Taro, Endo Miyoko, Inaba Toshiro, Maki Hisataka, Hatano Masaru, Yao Atsushi, Nishimura Takashi, Hirata Yasunobu, Kyo Shunei, Ono Minoru, Nagai Ryozo. A case of late-onset right ventricular failure after implantation of a continuous-flow left ventricular assist device. J Artif Organs. 2012;15(2):200-3.

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