研究実績(2021年)

英文論文(2021年)

Hirokawa M, Daimon M, Nakanishi K, Mahara K, Miyazaki S, Miyake M, Izumi C, Nakao T, Takeda N, Yatomi Y, Komuro I.
Longitudinal change in postoperative right ventricular systolic function in patients undergoing surgery for isolated tricuspid regurgitation.
Am Heart J Plus 2021;12:100073
Iwama K, Nakanishi K, Daimon M, Yoshida Y, Sawada N, Hirose K, Yamamoto Y, Ishiwata J, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
Chronic kidney disease and subclinical abnormalities of left heart mechanics in the community.
Eur Heart J Open 2021;1:oeab037
Minatsuki S, Kiyosue A, Shimizu Y, Tanikawa I, Murasawa T, Hirose K, Saito A, Yagi H, Takeda N, Hatano M, Ando J, Komuro I.
A Novel Technique of Balloon Pulmonary Angioplasty for the Treatment of Total Occlusion Lesions.
CJC Open 2021;3:1513-15
Morita H, Komuro I.
Salt Substitute and Cardiovascular Events and Death.
N Engl J Med 2021;385:2492-93
Hatano M, Jimba T, Fujiwara T, Tsuji M, Bujo C, Ishida J, Amiya E, Kinoshita O, Ono M.
Late-onset right ventricular failure after continuous-flow left ventricular assist device implantation: case presentation and review of the literature.
J Cardiol 2022 Aug;80:110-15
Kadowaki H, Ishida J, Uehara M, Ishizuka M, Kiyosue A, Hatano M, Shimada S, Ono M, Akazawa H, Komuro I.
Detection of Profound Myocardial Damage by Cardiac MRI in a Patient with Severe Cardiotoxicity Induced by Anti-HER2 Therapy.
Int Heart J 2021;62:1436-41
Katsushika S, Kodera S, Nakamoto M, Ninomiya K, Inoue S, Sawano S, Kakuda N, Takiguchi H, Shinohara H, Matsuoka R, Ieki H, Higashikuni Y, Nakanishi K, Nakao T, Seki T, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I.
The Effectiveness of a Deep Learning Model to Detect Left Ventricular Systolic Dysfunction from Electrocardiograms.
Int Heart J 2021;62:1332-41
Amiya E.
Link between hyperuricemia, renal dysfunction, and hypertension.
J Clin Hypertens (Greenwich) 2021 Dec;23:2078-79
Yoshida Y, Nakanishi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
Atrioventricular and Ventricular Functional Interdependence in Individuals Without Overt Cardiac Disease.
J Am Heart Assoc 2021;10:e021624
Koseki K, Yoon SH, Kaewkes D, Koren O, Patel V, Chakravarty T, Nakamura M, Cheng W, Komuro I, Makkar R.
Impact of Pulmonary Artery Dilatation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.
JACC Cardiovasc Interv 2021;14:2560-69
Higashikuni Y, Liu W, Obana T, Sata M.
Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications.
Int J Mol Sci 2021 Nov 8;22
Bujo C, Amiya E, Hatano M, Ishida J, Tsuji M, Kakuda N, Narita K, Saito A, Yagi H, Ando M, Shimada S, Kimura M, Kinoshita O, Ono M, Komuro I.
Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study.
Int J Cardiol Heart Vasc 2021;37:100907
Kaneko H, Yano Y, Itoh H, Morita K, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Nishiyama A, Node K, Bakris G, Miura K, Muntner P, Viera AJ, Oparil S, Lloyd-Jones DM, Yasunaga H, Komuro I.
Untreated Hypertension and Subsequent Incidence of Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.
J Am Heart Assoc 2021;10:e022479
Goto K, Uehara M, Okamoto K, Takeda N, Morita H, Hatano M, Komuro I.
The therapeutic dilemma of immunosuppressive drugs for refractory cardiac sarcoidosis in COVID-19 infection.
ESC Heart Fail 2021;8:5577-82
Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Maemura S, Suzuki T, Takiguchi H, Kubota Y, Seo K, Sakata A, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Nishimura S, Komuro I.
Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice.
Circulation 2021;144:1452-55
Sawada N, Nakanishi K, Daimon M, Hirose K, Yoshida Y, Ishiwata J, Hirokawa M, Koyama K, Nakao T, Morita H, Di Tullio MR, Homma S, Komuro I.
Independent effect of visceral fat on left atrial phasic function in the general population.
Nutr Metab Cardiovasc Dis 2021;31:3426-33
Kimura K, Morita H.
Cardiovascular Complications by EGFR Tyrosine Kinase Inhibitors in Patients with Lung Cancer.
Int Heart J 2021;62:949-51
Suzuki T, Hirose K, Tabei F, Sugishita Y, Oka T, Ishii S, Fujiwara T, Takeda N, Komuro I, Itoh N.
An Autopsy Case of Pulmonary Veno-Occlusive Disease Complicated with Chronic Obstructive Pulmonary Disease and Severe Pulmonary Hypertension.
Int Heart J 2021;62:1186-90
Oshima T, Fujiu K, Matsunaga H, Matsuda J, Matsubara T, Saga A, Yoshida Y, Shimizu Y, Hasumi E, Oguri G, Kojima T, Komuro I.
Uninterrupted Direct Oral Anticoagulants Without a Change in Regimen for Catheter Ablation for Atrial Fibrillation Is an Acceptable Protocol.
Circ Rep 2021;3:481-87
Minatsuki S, Takahara M, Kiyosue A, Kodera S, Hatano M, Ando J, Kohsaka S, Ishii H, Shinke T, Amano T, Ikari Y, Komuro I.
Characteristics and in-hospital outcomes of patients undergoing balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a time-trend analysis from the Japanese nationwide registry.
Open Heart 2021;834521747
Jimba T, Kaneko H, Yano Y, Itoh H, Yotsumoto H, Seki H, Morita K, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Nishiyama A, Node K, Yasunaga H, Komuro I.
Relation of the Metabolic Syndrome to Incident Colorectal Cancer in Young Adults Aged 20 to 49 Years.
Am J Cardiol 2021;158:132-38
Kaneko H, Itoh H, Kamiya K, Morita K, Sugimoto T, Konishi M, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Acute-phase initiation of cardiac rehabilitation and clinical outcomes in hospitalized patients for acute heart failure.
Int J Cardiol 2021;340:36-41
Itoh H, Amiya E, Narita K, Shimbo M, Taya M, Komuro I, Hasegawa T, Makita S, Kimura Y.
Efficacy and Safety of Remote Cardiac Rehabilitation in the Recovery Phase of Cardiovascular Diseases: Protocol for a Multicenter, Nonrandomized, Single-Arm, Interventional Trial.
JMIR Res Protoc 2021;10:e30725
Itoh H, Kaneko H, Okada A, Yano Y, Morita K, Seki H, Kiriyama H, Kamon T, Fujiu K, Matsuoka S, Nakamura S, Michihata N, Jo T, Takeda N, Morita H, Nishiyama A, Node K, Yasunaga H, Komuro I.
Fasting Plasma Glucose and Incident Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.
J Clin Endocrinol Metab 2021;106:e4448-e58
Koseki K, Yoon SH, Kaewkes D, Koren O, Patel V, Kim I, Sharma R, Sekhon N, Chakravarty T, Nakamura M, Cheng W, Komuro I, Makkar R.
Impact of the Geriatric Nutritional Risk Index in Patients Undergoing Transcatheter Aortic Valve Implantation.
Am J Cardiol 2021;157:71-78
Shinohara H, Kodera S, Ninomiya K, Nakamoto M, Katsushika S, Saito A, Minatsuki S, Kikuchi H, Kiyosue A, Higashikuni Y, Takeda N, Fujiu K, Ando J, Akazawa H, Morita H, Komuro I.
Automatic detection of vessel structure by deep learning using intravascular ultrasound images of the coronary arteries.
PLoS One 2021;16:e0255577
Ishiwata J, Daimon M, Nakanishi K, Sugimoto T, Kawata T, Shinozaki T, Nakao T, Hirokawa M, Sawada N, Yoshida Y, Amiya E, Hatano M, Morita H, Yatomi Y, Komuro I.
Combined evaluation of right ventricular function using echocardiography in non-ischaemic dilated cardiomyopathy.
ESC Heart Fail 2021;8:3947-56
Kamon T, Kaneko H, Itoh H, Kiriyama H, Mizuno Y, Morita H, Takeda N, Yamamichi N, Komuro I.
Possible Gender Difference in the Association Between Abdominal Obesity, Chronic Inflammation, and Preclinical Atherosclerosis in the General Population.
Int Heart J 2021;62:837-42
Takeda N, Inuzuka R, Yagi H, Morita H, Ando M, Yamauchi H, Taniguchi Y, Porto KJ, Kanaya T, Ishiura H, Mitsui J, Tsuji S, Toda T, Ono M, Komuro I.
Clinical Impact of Copy Number Variation on the Genetic Diagnosis of Syndromic Aortopathies.
Circ Genom Precis Med 2021;14:e003458
Katoh M, Nomura S, Yamada S, Aburatani H, Komuro I.
Single-Cardiomyocyte RNA Sequencing to Dissect the Molecular Pathophysiology of the Heart.
Methods Mol Biol 2021;2320:183-92
Itoh H, Kaneko H, Fujiu K, Kiriyama H, Morita K, Kamon T, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Risk Factors and Lifestyles in the Development of Atrial Fibrillation Among Individuals Aged 20-39 Years.
Am J Cardiol 2021;155:40-44
Narita K, Amiya E.
Is branched-chain amino acid nutritional supplementation beneficial or detrimental in heart failure?
World J Cardiol 2021 Jun 26;13:163-69
Hirose K, Nakanishi K, Daimon M, Sawada N, Yoshida Y, Ishiwata J, Hirokawa M, Koyama K, Nakao T, Fujiu K, Morita H, Di Tullio MR, Homma S, Komuro I.
Correlation Between the Cohorts for Heart and Aging Research in Genomic Epidemiology-Atrial Fibrillation Risk Score and Left Atrial Remodeling in the General Population.
Circ Arrhythm Electrophysiol 2021;14:e009826
Katsushika S, Kodera S, Nakamoto M, Ninomiya K, Kakuda N, Shinohara H, Matsuoka R, Ieki H, Uehara M, Higashikuni Y, Nakanishi K, Nakao T, Takeda N, Fujiu K, Daimon M, Ando J, Akazawa H, Morita H, Komuro I.
Deep Learning Algorithm to Detect Cardiac Sarcoidosis From Echocardiographic Movies.
Circ J 2021;86:87-95
Seki H, Kaneko H, Morita H, Itoh H, Morita K, Matsuoka S, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Yano Y, Nakamura S, Node K, Yasunaga H, Komuro I.
Relation of Serum Uric Acid and Cardiovascular Events in Young Adults Aged 20-49 Years.
Am J Cardiol 2021;152:150-57
Nakayama A, Morita H, Kawahara T, Itoh H, Komuro I.
Association between testosterone and lipid profiles under statin therapy and its clinical impact on the cardiovascular event risk.
Heart Vessels 2021;36:1794-803
Matsuoka S, Kaneko H, Yano Y, Itoh H, Fukui A, Morita K, Kiriyama H, Kamon T, Fujiu K, Seki H, Michihata N, Jo T, Takeda N, Morita H, Nakamura S, Yokoo T, Nishiyama A, Node K, Yasunaga H, Komuro I.
Association Between Blood Pressure Classification Using the 2017 ACC/AHA Blood Pressure Guideline and Retinal Atherosclerosis.
Am J Hypertens 2021;34:1049-56
Kadowaki H, Akazawa H, Ishida J, Komuro I.
Mechanisms and Management of Immune Checkpoint Inhibitor-Related Cardiac Adverse Events.
JMA J 2021;4:91-98
Komuro I.
SARS-CoV-2 surreptitiously injures the heart of Japanese: echocardiography is useful in evaluating cardiac damage.
Glob Health Med 2021;3:60-61
Kaneko H, Yano Y, Itoh H, Morita K, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Node K, Carey RM, Lima JAC, Oparil S, Yasunaga H, Komuro I.
Association of Blood Pressure Classification Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Risk of Heart Failure and Atrial Fibrillation.
Circulation 2021;143:2244-53 
Kiriyama H, Kaneko H, Itoh H, Kamon T, Morita K, Jo T, Fujiu K, Daimon M, Takeda N, Morita H, Yasunaga H, Komuro I.
Surgical treatment for infective endocarditis in the ageing society: a nationwide retrospective study in Japan.
Open Heart 2021;833846222
Kadowaki H, Ishida J, Akazawa H, Yagi H, Saga-Kamo A, Umei M, Matsuoka R, Liu Q, Matsunaga H, Maki H, Sato Y, Kume H, Komuro I.
Axitinib Induces and Aggravates Hypertension Regardless of Prior Treatment With Tyrosine Kinase Inhibitors.
Circ Rep 2021;3:234-40
Komuro I, Kadowaki T, Bodegard J, Thuresson M, Okami S, Yajima T.
Lower heart failure and chronic kidney disease risks associated with sodium-glucose cotransporter-2 inhibitor use in Japanese type 2 diabetes patients without established cardiovascular and renal diseases.
Diabetes Obes Metab 2021;23 Suppl 2:19-27
Ito M, Morita H.
Titin Truncation Variant in Dilated Cardiomyopathy.
Int Heart J 2021;62:221-23
Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, Seno H, Asano K, Ishijima A, Tomii N, Yamazaki M, Kudo F, Sakuma I, Nagai R, Manabe I, Komuro I.
Cardiac macrophages prevent sudden death during heart stress.
Nat Commun 2021;12:1910 
Dai Z, Uehara M, Amiya E, Hatano M, Komuro I.
Acute cellular rejection after heart transplantation and its remission visualized by cardiac magnetic resonance.
Eur Heart J Case Rep 2021;5:ytab085
Kakuda N, Amiya E, Hatano M, Maki H, Bujo C, Tsuji M, Narita K, Fujita K, Ishida J, Ono M, Komuro I.
Case Report: A Case of Acute Cellular Rejection Due to Atopic Dermatitis Exacerbation 3 Years After Heart Transplantation.
Front Immunol 2021;12:630051
Saito Y, Nakayama A, Sato T, Morita H, Kawahara T, Itoh H, Komuro I.
Lipid-lowering statin therapy is beneficial in elderly female patients with hypercholesterolaemia and diabetic retinopathy.
Eur J Prev Cardiol 2021;28:e7-e9
Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Possible association between eating behaviors and cardiovascular disease in the general population: Analysis of a nationwide epidemiological database.
Atherosclerosis 2021;320:79-85
Ishizuka M, Harada M, Nomura S, Ko T, Ikeda Y, Guo J, Bujo S, Yanagisawa-Murakami H, Satoh M, Yamada S, Kumagai H, Motozawa Y, Hara H, Fujiwara T, Sato T, Takeda N, Otsu K, Morita H, Toko H, Komuro I.
CXCR7 ameliorates myocardial infarction as a beta-arrestin-biased receptor.
Sci Rep 2021;11:3426
Itoh H, Kaneko H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the General Population - Analysis of a Nationwide Epidemiological Database.
Circ J 2021;85:914-20
Kaneko H, Kiriyama H, Kamon T, Itoh H, Kodera S, Fujiu K, Daimon M, Morita H, Hatano M, Komuro I.
Percutaneous Mitral Valve Intervention Using MitraClip for Functional Mitral Regurgitation and Heart Failure.
Int Heart J 2021;62:4-8
Kaneko H, Itoh H, Yotsumoto H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Impact of hospital volume on clinical outcomes of hospitalized heart failure patients: analysis of a nationwide database including 447,818 patients with heart failure.
BMC Cardiovasc Disord 2021;21:49
Hirose K, Nakanishi K, Daimon M, Sawada N, Yoshida Y, Iwama K, Yamamoto Y, Ishiwata J, Hirokawa M, Koyama K, Nakao T, Morita H, Di Tullio MR, Homma S, Komuro I.
Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community.
Cardiovasc Diabetol 2021;20:22
Tsuji M, Amiya E, Bujo C, Hara T, Saito A, Minatsuki S, Maki H, Ishida J, Hosoya Y, Hatano M, Imai H, Nemoto M, Kagami Y, Endo M, Kimura M, Ando M, Shimada S, Kinoshita O, Ono M, Komuro I.
Carbon Monoxide Diffusing Capacity Predicts Cardiac Readmission in Patients Undergoing Left Ventricular Assist Device Implantation in Japan.
ASAIO J 2021;67:1111-18
Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Fasting plasma glucose and subsequent cardiovascular disease among young adults: Analysis of a nationwide epidemiological database.
Atherosclerosis 2021;319:35-41
Oguri G, Nakajima T, Kikuchi H, Obi S, Nakamura F, Komuro I.
Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1.
Heliyon 2021;7:e05816
Kaneko H, Itoh H, Morita K, Sugimoto T, Konishi M, Kamiya K, Kiriyama H, Kamon T, Fujiu K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Early Initiation of Feeding and In-Hospital Outcomes in Patients Hospitalized for Acute Heart Failure.
Am J Cardiol 2021;145:85-90
Adachi Y, Kiyosue A, Ando J, Kawahara T, Kodera S, Minatsuki S, Kikuchi H, Inaba T, Kiriyama H, Hirose K, Shinohara H, Saito A, Fujiwara T, Hara H, Ueda K, Sakakura K, Hatano M, Harada M, Takimoto E, Akazawa H, Morita H, Momomura SI, Fujita H, Komuro I.
Factors associated with left ventricular reverse remodelling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction.
Sci Rep 2021;11:239
Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
Relation of Body Mass Index to Adverse Right Ventricular Mechanics.
Am J Cardiol 2021;144:137-42
Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Lipid Profile and Subsequent Cardiovascular Disease among Young Adults Aged < 50 Years.
Am J Cardiol 2021;142:59-65
Nomura S, Komuro I.
Precision medicine for heart failure based on molecular mechanisms: The 2019 ISHR Research Achievement Award Lecture.
J Mol Cell Cardiol 2021;152:29-39
Sawano S, Nakayama A, Morita H, Komuro I.
Rathke’s cleft cyst induced cardiac arrest.
Eur Heart J 2021;42:714
Bujo C, Amiya E, Hatano M, Tsuji M, Maki H, Ishida J, Ishii S, Narita K, Endo M, Ando M, Shimada S, Kinoshita O, Ono M, Komuro I.
Association between infectious event and de novo malignancy after heart transplantation.
Heart Vessels 2021;36:499-508
Nakanishi K, Daimon M, Yoshida Y, Sawada N, Hirose K, Iwama K, Yamamoto Y, Ishiwata J, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
Subclinical Hypothyroidism as an Independent Determinant of Left Atrial Dysfunction in the General Population.
J Clin Endocrinol Metab 2021;106:e1859-e67
Itoh H, Kaneko H, Kiriyama H, Kamon T, Fujiu K, Morita K, Yotsumoto H, Michihata N, Jo T, Takeda N, Morita H, Yasunaga H, Komuro I.
Reverse J-shaped relationship between body mass index and in-hospital mortality of patients hospitalized for heart failure in Japan.
Heart Vessels 2021;36:383-92
Kaneko H, Itoh H, Yotsumoto H, Kiriyama H, Kamon T, Fujiu K, Morita K, Kashiwabara K, Michihata N, Jo T, Morita H, Yasunaga H, Komuro I.
Cardiovascular Health Metrics of 87,160 Couples: Analysis of a Nationwide Epidemiological Database.
J Atheroscler Thromb 2021;28:535-43
Yoshida Y, Nakanishi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
Sex-specific difference in the association between arterial stiffness and subclinical left ventricular dysfunction.
Eur Heart J Cardiovasc Imaging 2021;22:817-23
Kiriyama H, Kaneko H, Itoh H, Kamon T, Mizuno Y, Fujiu K, Morita H, Yamamichi N, Komuro I.
Association between changes in body weight and lipid profile in the general population: a community-based cohort study.
Eur Heart J Qual Care Clin Outcomes 2021;7:109-10

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