研究実績（2024年）

Goto K, Soma K, Tokiwa H, Umei M, Saito A, Fujiu K, Inuzuka R, Hirata Y, Takeda N, Yao A.

Tricuspid Regurgitation Stratification Predicts the Time Course of Systemic Right Ventricle Dysfunction Among Patients on ACE-I/ARB.

CJC Pediatr Congenit Heart Dis 2024;3:191-99

Hiruma T, Inoue S, Ko T, Nomura S, Abe R, Bujo C, Ishida J, Takeda N, Amiya E, Hatano M, Abe H, Morita H, Ono M, Takeda N, Komuro I.

PRKAG2 Syndrome Caused by a Novel Missense Variant Mimicked Sporadic Hypertrophic Cardiomyopathy Until Its Progression to Burned-Out Phase.

Circulation: Heart Failure 2024;17:e012047

Shimbo M, Hatano M, Katsushika S, Kodera S, Isotani Y, Sawano S, Matsuoka R, Minatsuki S, Inaba T, Maki H, Sumida H, Takeda N, Akazawa H, Komuro I.

Vertebral osteomyelitis secondary to infective endocarditis detected by repeated magnetic resonance imaging: a case report.

International Heart Journal 2024;65:1066-74

Oguri G, Ikegami R, Ugawa H, Katoh M, Obi S, Sakuma M, Takeda N, Kano Y, Toyoda S, Nakajima T.

Muscle Atrophy and mRNA-miRNA Network Analysis of Vascular Endothelial Growth Factor (VEGF) in a Mouse Model of Denervation-Induced Disuse.

Cureus 2024;16:e68974

Morishita K, Fujiu K, Yamagata K, Amiya E, Takeda N.

Right ventricular myocardial biopsy with a guiding catheter for conduction system pacing during pacemaker implantation revealed transthyretin cardiac amyloidosis.

HeartRhythm Case Rep 2024;10:635-38

Hiruma T, Inoue S, Dai Z, Nomura S, Kubo T, Sugiura K, Suzuki A, Kashimura T, Matsushima S, Yamada T, Tobita T, Katoh M, Ko T, Ito M, Ishida J, Amiya E, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Tsutsui H, Kitaoka H, Aburatani H, Takeda N, Komuro I.

Association of Multiple Nonhypertrophic Cardiomyopathy-Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy.

JACC Heart Fail 2024;12:2041-52

Ko T, Kaneko H, Suzuki Y, Okada A, Azegami T, Fujiu K, Takeda N, Morita H, Yokoo T, Hayashi K, Komuro I, Yasunaga H, Nangaku M, Takeda N.

Dose-dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset.

European Journal of Clinical Investigation 2025;55:e14322

Inoue S, Ko T, Shindo A, Nomura S, Yamada T, Jimba T, Dai Z, Nakao H, Suzuki A, Kashimura T, Iwahana T, Goto K, Matsushima S, Ishida J, Amiya E, Zhang B, Kubota M, Sawami K, Heryed T, Yamada S, Katoh M, Katagiri M, Ito M, Nayakama Y, Fujiu K, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Kobayashi Y, Minamino T, Tsutsui H, Kurokawa M, Aiba A, Aburatani H, Komuro I.

Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy.

JACC Basic Transl Sci 2024;9:956-67

Ito M, Katoh M, Sassa T, Ko T, Fujita K, Yamada S, Miura K, Toyoda M, Takada S, Tobita T, Katagiri M, Kubota M, Yamada T, Hatsuse S, Morita H, Ikeuchi M, Matsuura K, Umezawa A, Nomura S, Aburatani H, Komuro I.

LMNA Q353R Mutation Causes Dilated Cardiomyopathy Through Impaired Vitamin D Signaling.

Circulation 2024;150:971-74

Fukuma N, Tokiwa H, Numata G, Ueda K, Liu PY, Tajima M, Otsu Y, Kariya T, Hiroi Y, Liao JK, Komuro I, Takimoto E.

Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload.

Cardiovascular Research 2024;120:1884-97

Nakanishi K, Daimon M, Fujiu K, Iwama K, Hirose K, Yoshida Y, Mukai Y, Seki H, Yamamoto Y, Hirokawa M, Nakao T, Oshima T, Matsubara T, Shimizu Y, Oguri G, Kojima T, Hasumi E, Morita H, Kurano M, Komuro I.

Prevalence of Abnormal Atrial and Ventricular Mechanics and Its Reversibility in Patients With Atrial Fibrillation.

JACC: Cardiovascular Imaging 2024;17:1504-06

Dai Z, Ko T, Inoue S, Nomura S, Fujita K, Onoue K, Kuramoto Y, Asano Y, Katoh M, Yamada S, Katagiri M, Zhang B, Yamada T, Heryed T, Sawami K, Jimba T, Hori N, Kubota M, Ito M, Amiya E, Hatano M, Takeda N, Morita H, Saito Y, Takeda N, Komuro I.

Myocardial DNA Damage Is Responsible for the Relationship Between Genotype and Reverse Remodeling in Patients With Dilated Cardiomyopathy.

Circulation: Heart Failure 2024;17:e011879

Nishijo D, Yagi H, Akiyama N, Takeda N, Ando M, Yamauchi H, Takeda N, Komuro I.

A De Novo Missense MYLK Variant Leading to Nonsyndromic Thoracic Aortic Aneurysm and Dissection Identified by Segregation Analysis.

Case Rep Genet 2024;2024:4281972

Sawano S, Kodera S, Setoguchi N, Tanabe K, Kushida S, Kanda J, Saji M, Nanasato M, Maki H, Fujita H, Kato N, Watanabe H, Suzuki M, Takahashi M, Sawada N, Yamasaki M, Sato M, Katsushika S, Shinohara H, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I.

Applying masked autoencoder-based self-supervised learning for high-capability vision transformers of electrocardiographies.

PloS One 2024;19:e0307978

Aono-Setoguchi H, Yagi H, Akiyama N, Takeda N, Ando M, Yamauchi H, Komuro I, Takeda N.

Management of an elderly patient with nonsyndromic TGFBR1-related aortopathy: A case report.

Clin Case Rep 2024;12:e9317

Ko T, Suzuki Y, Kaneko H, Jimba T, Fujiu K, Takeda N, Morita H, Yasunaga H, Takeda N, Komuro I.

Rate of subsequent diagnosis of sarcoidosis after pacemaker implantation for atrioventricular block: an analysis of a nationwide epidemiological dataset.

Eur J Prev Cardiol 2024;31:2141-43

Minatsuki S, Hatano M, Hirose K, Saito A, Yagi H, Takeda N, Komuro I.

Differential effects of balloon pulmonary angioplasty on chronic thromboembolic pulmonary disease.

Heart 2024;110:1133-38

Jimba T, Kaneko H, Azegami T, Suzuki Y, Okada A, Ko T, Fujiu K, Takeda N, Morita H, Hayashi K, Nishiyama A, Node K, Yasunaga H, Takeda N, Nangaku M, Komuro I.

Body weight change associated kidney outcomes of sodium-glucose cotransporter new users.

Diabetes, Obesity & Metabolism 2024;26:4535-43

Katoh M, Nomura S, Yamada S, Ito M, Hayashi H, Katagiri M, Heryed T, Fujiwara T, Takeda N, Nishida M, Sugaya M, Kato M, Osawa T, Abe H, Sakurai Y, Ko T, Fujita K, Zhang B, Hatsuse S, Yamada T, Inoue S, Dai Z, Kubota M, Sawami K, Ono M, Morita H, Kubota Y, Mizuno S, Takahashi S, Nakanishi M, Ushiku T, Nakagami H, Aburatani H, Komuro I.

Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7.

Circulation 2024;150:374-89

Hiruma T, Amiya E, Ueda T, Bujo C, Isotani Y, Tsuji M, Ito M, Minatsuki S, Ishida J, Takeda N, Hatano M, Abe H, Nakagama Y, Komuro I.

Successful treatment of fulminant and recurrent lymphocytic myocarditis with calcineurin inhibitors. ESC Heart Fail 2024;11:3430-37

ESC Heart Fail 2024;11:3430-37

Hirose K, Nakanishi K, Daimon M, Iwama K, Yoshida Y, Mukai Y, Yamamoto Y, Seki H, Hirokawa M, Nakao T, Oshima T, Matsubara T, Shimizu Y, Oguri G, Kojima T, Hasumi E, Fujiu K, Morita H, Kurano M, Komuro I.

Body Fat Distribution and Left Atrial Reverse Remodeling After Catheter Ablation for Atrial Fibrillation.

JACC Adv 2024;3:100973

Shinohara H, Kodera S, Nagae Y, Hiruma T, Kobayashi A, Sato M, Sawano S, Kamon T, Narita K, Hirose K, Kiriyama H, Saito A, Miura M, Minatsuki S, Kikuchi H, Takeda N, Akazawa H, Morita H, Komuro I.

The potential of the transformer-based survival analysis model, SurvTrace, for predicting recurrent cardiovascular events and stratifying high-risk patients with ischemic heart disease.

PloS One 2024;19:e0304423

Soma K, Ochiai R, Tsutsui H, Takeda N, Yao A.

Nationwide Survey on Transitional Care for Patients With Childhood-Onset Cardiomyopathy in Japan.

Circ Rep 2024;6:209-16

Goto K, Kojima T, Oshima T, Saito A, Shimizu Y, Soma K, Nakayama Y, Hasumi E, Inuzuka R, Ando M, Amiya E, Fujiu K, Hirata Y, Hatano M, Ono M, Komuro I.

A leadless pacemaker implantation for a patient with systemic right ventricle under ventricular assist device support.

J Cardiol Cases 2024;29:244-47

Itoh H, Amiya E, Jimba T, Shimbo M, Narita K, Taya M, Kadokami T, Yasu T, Oka H, Sogawa M, Yokoi H, Mizutani K, Miura SI, Tokeshi T, Date A, Noma T, Kutsuzawa D, Usui S, Sugawara S, Kanazawa M, Sekino H, Nishitani Yokoyama M, Okumura T, Ugata Y, Fujishima S, Hirabayashi K, Ishizaki Y, Kuwahara K, Kaji Y, Shimizu H, Koyama T, Adachi H, Kurumatani Y, Taniguchi R, Ohori K, Shiraishi H, Hasegawa T, Makita S, Komuro I, Kimura Y, Rec RCRri.

Efficacy and safety of remote cardiac rehabilitation in the recovery phase of cardiovascular diseases (RecRCR study): A multicenter, nonrandomized, and interventional trial in Japan.

Int J Cardiol Heart Vasc 2024;52:101421

Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I.

Heart failure promotes multimorbidity through innate immune memory.

Sci Immunol 2024;9:eade3814

Okamura S, Bujo C, Amiya E, Kurokawa K, Hatano M, Ishida J, Tsuji M, Ihara S, Murakami K, Shiomi C, Hayakawa Y, Fujishiro M, Ono M, Komuro I. Native T1 mapping in early diffuse and limited systemic sclerosis, and its association with diastolic function.

The first case report of de novo Crohn’s disease after heart transplantation successfully treated with ustekinumab.

J Cardiol Cases 2024;29:174-77

Ko T, Komuro I.

A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy.

JACC Basic Transl Sci 2024;9:396-98

Nishijo D, Nakanishi K, Kono M, Shimada S, Komuro I.

A Rare Case of Coronary Involvement in IgG4-Related Disease.

JACC Case Rep 2024;29:102254

Oshima T, Yamagata K, Shimizu Y, Koizumi S, Fujiu K, Komuro I.

Iatrogenic vertebral artery injury during catheter ablation treated using coil embolization.

Pacing and Clinical Electrophysiology 2024;47:1370-72

Oida M, Mizutani T, Hasumi E, Fujiu K, Goto K, Kani K, Oshima T, Matsubara TJ, Shimizu Y, Oguri G, Kojima T, Komuro I.

Prediction of pacemaker-induced cardiomyopathy using a convolutional neural network based on clinical findings prior to pacemaker implantation.

Scientific Reports 2024;14:6916

Ko T, Suzuki Y, Kaneko H, Jimba T, Komuro J, Okada A, Fujiu K, Takeda N, Morita H, Node K, Yasunaga H, Takeda N, Komuro I.

Applying the HARMS2-atrial fibrillation risk score for Japanese population: an analysis of a nationwide epidemiological dataset.

Eur J Prev Cardiol 2024;31:1738-40

Ishii S, Hatano M, Minatsuki S, Hirose K, Saito A, Yagi H, Shimbo M, Soma K, Konoeda C, Sato M, Nakajima J, Komuro I.

Comprehensive Risk Assessment in Patients With Pulmonary Arterial Hypertension Referred for Lung Transplantation.

Circulation Journal 2024;88:1610-17

Tsuji M, Kurihara T, Isotani Y, Bujo C, Ishida J, Amiya E, Hatano M, Shimada A, Imai H, Kimura M, Shimada S, Ando M, Ono M, Komuro I.

Right Heart Reserve Function Assessed With Fluid Loading Predicts Late Right Heart Failure After Left Ventricular Assist Device Implantation.

Canadian Journal of Cardiology 2024;40:1745-54

Kaneko H, Yano Y, Okada A, Itoh H, Suzuki Y, Yokota I, Morita K, Fujiu K, Michihata N, Jo T, Yamaguchi Sawano S, Kodera S, Sato M, Shinohara H, Kobayashi A, Takiguchi H, Hirose K, Kamon T, Saito A, Kiriyama H, Miura M, Minatsuki S, Kikuchi H, Takeda N, Morita H, Komuro I.

Multimodality Risk Assessment of Patients with Ischemic Heart Disease Using Deep Learning Models Applied to Electrocardiograms and Chest X-rays.

International Heart Journal 2024;65:29-38

Abe R, Ko T, Inoue S, Nomura S, Jimba T, Katoh M, Ito M, Ishida J, Amiya E, Takeda N, Hatano M, Morita H, Ono M, Takeda N, Komuro I.

A Pathogenic LAMP2 Non-Canonical Splice Site Mutation Caused Danon Disease Requiring Heart Transplantation.

Circulation Journal 2024;88:612

Jimba T, Hatano M, Fujiwara T, Akazawa H, Watanabe M, Kinugawa K, Ono M, Komuro I.

A case of progressive right ventricular failure with ventricular arrhythmia and aortic insufficiency after implantable left ventricular assist device implantation.

J Cardiol Cases 2024;29:7-10

Hirose K, Nakanishi K, Daimon M, Iwama K, Yoshida Y, Mukai Y, Yamamoto Y, Nakao T, Oshima T, Matsubara T, Shimizu Y, Oguri G, Kojima T, Hasumi E, Fujiu K, Morita H, Komuro I.

Association of Atrial Fibrillation Progression With Left Atrial Functional Reserve and Its Reversibility.

J Am Heart Assoc 2024;13:e032215

Kadowaki H, Akazawa H, Shindo A, Ueda T, Ishida J, Komuro I.

Shared and Reciprocal Mechanisms Between Heart Failure and Cancer　- An Emerging Concept of Heart-Cancer Axis.

Circulation Journal 2024;88:182-88

Hasumi E, Fujiu K, Nakamura K, Yumino D, Nishii N, Imai Y, Shoda M, Komuro I.

A mutually communicable external system resource in remote monitoring for cardiovascular implantable electronic devices.

Pacing and Clinical Electrophysiology 2024;47:127-30

Dai Z, Ko T, Fujita K, Nomura S, Uemura Y, Onoue K, Hamano M, Katoh M, Yamada S, Katagiri M, Zhang B, Hatsuse S, Yamada T, Inoue S, Kubota M, Sawami K, Heryed T, Ito M, Amiya E, Hatano M, Takeda N, Morita H, Yamanishi Y, Saito Y, Komuro I.

Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases.

Matsuoka Y, Sotomi Y, Hikoso S, Nakatani D, Okada K, Dohi T, Kida H, Oeun B, Sunaga A, Sato T, Kitamura T, Sakata Y, Sato H, Hori M, Komuro I, Sakata Y.

The Prognostic Impact of In-Hospital Major Bleeding and Recurrence of Myocardial Infarction during Acute Phase after Percutaneous Coronary Intervention for Acute Myocardial Infarction.

J Atheroscler Thromb 2024;31:158-70