心エコーの臨床研究

現在行っている臨床研究

現在心エコーグループでは、より良い診断法や治療法の開発を目指して様々な臨床研究を行っております。国内外の施設との共同研究も行っております。現在進めている主な研究は次の通りです。このほか、基礎研究と臨床研究をトランスレーショナルに結ぶような横断的研究も予定しております。興味のある方は外部からでも参加可能です。また他の分野の研究者の方との共同研究も歓迎いたしますので、ご連絡ください。

・機能性僧帽弁逆流における代償性僧帽弁伸展に関する3次元心エコー解析
・心エコー正常値の人種差を検討する国際共同研究(米国心エコー図学会主導のWASE study)
・肥満が左室拡張能に与える影響について(米国コロンビア大学と共同研究)
・人工弁置換術後の予後に関する多施設共同研究
・補助人工(LVAD)植え込み後の右心機能が予後に与える影響に関する多施設共同研究
・筋ジストロフィーに合併する心筋症の予後に関する多施設共同研究
・肺高血圧症が右心機能に与える影響に関する研究
・内臓脂肪と左室拡張障害に関する研究
・糖尿病性心筋症に関する研究
・大動脈弁狭窄症の予後に関する多施設共同研究
・2D speckle tracking法を用いた心機能評価に関する研究
・薬剤介入後の心機能評価に関する研究
・肥大型心筋症の新たな病型分類に関する研究
・交代勤務者の心脳血管障害発症リスク低減のための研究
・虚血性心疾患の再発予防のための研究(イタマーメディカルジャパン株式会社と共同研究

主な受賞、研究助成(5年以内)

1. 独立行政法人日本学術振興会 平成24~26年度科学研究費基盤C 研究課題「心筋ストレインを用いた新たな左室拡張能指標の確立」(主任研究者 大門雅夫)

2. 独立行政法人日本学術振興会 平成27~29年度科学研究費基盤C 研究課題「代償性僧帽弁伸展の破綻:3次元心エコーによる新たな虚血性僧帽弁逆流発症機序の解明」(主任研究者 大門雅夫)

3. 独立行政法人日本学術振興会 平成26~28年度科学研究費若手研究B 研究課題「高血圧患者における不眠症の診断および治療意義の検討」(主任研究者 中尾倫子)

4. 独立行政法人日本学術振興会 平成27~29年度科学研究費基盤C 研究課題「Handgrip負荷スペックルトラッキング法を用いた糖尿病性心筋障害の病態解明」(主任研究者 川田貴之)

5. 平成27年度 日本超音波医学会 伊東賞 福田延昭「Prolonged vortex formation during the ejection period in the left ventricle with low ejection fraction : a study by vector flow mapping.」

6. 平成27年度公益信託臨床検査医学研究振興基金 研究奨励金 「高齢者の拡張性心不全予防を目指した左室拡張機能に与える生活習慣および臨床背景の解明」(主任研究者 大門雅夫)

7. 独立行政法人日本学術振興会 平成29~31年度科学研究費基盤C 研究課題「自律神経に着目したジストロフィン異常心筋症の治療開発-最大死因の解決を目指す」(17k07092)(主任研究者 木村公一)

8. 独立行政法人日本学術振興会平成29~31年度 基盤研究C「血小板機能に対する交代勤務の影響〜交代勤務者の心脳血管障害リスク低減をめざして」 (17K09227) (主任研究者 中尾倫子)

9. 第243回 日本循環器学会関東甲信越地方会 Clinical Research Award 最優秀賞 川田 貴之

発表論文

Hirose K, Daimon M, Miyazaki S, Chiang SJ, Morimoto-Ichikawa R, Maruyama M, Kawata T, Ohmura H, Daida H. Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women. J Cardiol. 2017; 69(1):389-393.

Myojo, M, Ando , Uehara M, Daimon M, Watanabe M, Komuro I. Feasibility of extracorporeal shock wave myocardial revascularization therapy for post-acute myocardial infarction patients and refractory angina pectoris patients. Int Heart J 2017 Mar 21. doi: 10.1536/ihj.16-289. [Epub ahead of print]

Kawata T, Daimon M, Lee SL, Kimura K, Sawada N, Chiang SJ, Mahara K, Okubo T, Nakao T, Hirokawa M, Xu B, Kato T, Watanabe M, Yatomi Y, Komuro I. Reconsideration of Inferior Vena Cava Parameters for Estimating Right Atrial Pressure in an East Asian Population: A Comparative Simultaneous Ultrasound-Catheterization Study. Circ J 2017; 81:346–352.

Lin HC, Daimon M, Wang CH, Ho Y, Uang YS, Chiang SJ, Wang LH. Allopurinol, Benzbromarone and risk of coronary heart disease in gout patients: a population-based study. Int J Cardiol 2017; 233: 85-90.

Numata N, Makinae H, Yoshida W, Daimon M, Murakami H. Disaster Victim Identification using Orthopedic Implants in the 2011 East-Japan Earthquake and Tsunami. Tohoku J Exp Med 2017; 241: 219-223.

Kawata T, Daimon M, Kimura K, Nakao T, Lee SL, Hirokawa M, Kato T, Watanabe M, Yatomi Y, Komuro I. Echocardiographic assessment of right ventricular function in routine practice: Which parameters are useful to predict one-year outcome in advanced heart failure patients with dilated cardiomyopathy? J Cardiol 2017, in press.

Chiang SJ, Daimon M, Miyazaki S, Kawata T, Ichikawa-Morimoto R ,Maruyama M, Ohmura H, Miyauchi K, Lee SL, Daida H. When and how aortic stenosis is first diagnosed: a single-center observational study. J Cardiol 2016;68(4):324-8.

Shibayama K , Daimon M, Watanabe H, Kawata T, Miyazaki S, Morimoto-Ichikawa R, Maruyama M, Chiang SJ, Miyauchi K, Daida H. Significance of Coronary Artery Disease and Left Ventricular Afterload in Unoperated Asymptomatic Aortic Stenosis. Circ J 2016: 80(2): 519-525

Hirokawa M, Daimon M, Lee SL, Nakao T, Kawata T, Kimura K, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I. Early menopause does not influence left ventricular diastolic dysfunction: A clinical observational study in healthy subjects. J Cardiol 2016: 68: 548-553

Lee SL, Daimon M, Nakao T, Singer DE, Shinozaki T, Kawata T, Kimura K, Hirokawa M, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I. Factors Influencing Left Atrial Volume in a Population with Preserved Ejection Fraction: Left Ventricular Diastolic Dysfunction or Clinical Factors?  J Cardiol. 2016; 68(4):275-81.

Akaishi M, Asanuma T, Izumi C, Iwanaga S, Kawai H, Daimon M, Toide H, Hashimoto S, Hayashida A, Yamada H, Nakatani S.  Guidelines for conducting transesophageal echocardiography (TEE) : Task force for guidelines for conducting TEE: November 15, 2015.  J Echocardiogr 2016, 14(2):47-8.

Xu B, Daimon M. Cardiac aging phenomenon and its clinical features by echocardiography. J Echocardiogr 2016;14(4):139-145.

Kimura K, Morita H, Daimon M, Horio M, Kawata T, Nakao T, Hirokawa M, Kitao R, Watanabe D, Komori T, Nagata T, Takeda S, Komaki H, Segawa K, Nakajima T, Takenaka K, Komuro I. Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy. Int Heart J. 2016;57(3):386-8.

Lee SL, Daimon M, Di Tullio MR, Homma S, Nakao T, Kawata T, Kimura K; Shinozak T, Hirokawa M, Kato T, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I. Relation of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population with Preserved Left Ventricular Ejection Fraction. Circ J. 2016 ;80(9):1951-6.

Kimura K, Morita H, Nakamura A, Takenaka K, Daimon M. Therapeutic strategy for Heart Failure in Becker Muscular Dystrophy. Int Heart J 2016; 57(5):527-9.

Kido Y, Takahashi M, Fukuma N, Kawata T, Tanaka A, Hayashi A, Shibahara J, Daimon M, Morita H, Akazawa H, Komuro I. Heart Failure Complicated by Alveolar Hemorrhage due to Vascular Collapse and Amyloid Deposits in Wild-Type Transthyretin Amyloidosis. Cardiology. 2016 ;135(4):216-220.

Murata A, Inoue K, Maruyama S, Iguchi S, Sugita M, Hiki M, Okazaki S, Okai I, Fujiwara Y, Sumiyoshi M, Yamamoto T, Amano A, Daimon M, Daida H. Enormous Pedunculated Vegetation Originating in the Left Ventricular Apex in a Patient with Infective Endocarditis. Intern Med. 2016;55(20):2971-2973.

Otsuji Y, Seo Y, Daimon M, Takeuchi M, Yuasa T. Echocardiographic diagnosis of adult valvular heart disease. Journal of Medical Ultrasonic 2016; 43(4): 557-597.

Nakao T, Morita H. Neuromuscular Electrical Stimulation in Patients With Acute Myocardial Infarction. Int Heart J. 2016;57(6):659-660.

Maruo T, Seo Y, Yamada S, Arita T, Ishizu T, Shiga T, Dohi K, Toide H, Furugen A, Inoue K, Daimon M, Kawai H, Tsuruta H, Nishigami K, Yuda S, Ozawa T, Izumi C, Fumikura Y, Wada Y, Doi M, Okada M, Takenaka K, Aonuma K. The Speckle Tracking Imaging for the Assessment of Cardiac Resynchronization Therapy (START) Study. Circ J, 2015; 79(3):613-22.

Chiang SJ, Daimon M, Wang LH, Hung MJ, Chang NC, Lin HC. Association between Mitral Valve Prolapse and Open-Angle Glaucoma. Heart 2015; 101(8):609-15.

Fukuda S, Watanabe H, Iwakura K, Daimon M, Ito H, Yoshikawa J. Multi-center Investigations of the Prevalence of Abdominal Aortic Aneurysm in Elderly Japanese Patients with Hypertension: the AAA Japan Study, Circ J 2015; 79(3):524-9.

Kimura K, Daimon M, Morita H, Kawata T, Nakao T, Okano T, Lee S, Takenaka K, Nagai R, Yatomi Y, Komuro I. Evaluation of Right Ventricle by Speckle Tracking and Conventional Echocardiography in Rats with Right Ventricular Heart Failure. Int Heart J 2015; 56(3):349-53.

Nakatani S, Akaishi M, Asanuma T, Hashimoto S, Izumi C, Iwanaga S, Kawai H, Daimon M, Toide H, Hayashida H, Yamada H. Guidelines from the Japanese Society of Echocardiography: Guidance for the management and maintenance of echocardiography equipment. J Echocardiogr 2015; 13:1-5

Kimura K, Morita K, Daimon M,,Kawata T,,Nakao T, Lee SL, Hirokawa M, Ebihara A, Nakajima T, Ozawa T, Yonemochi Y, Aida I, Motoyoshi Y, Mikata T, Uchida I, Komori T, Kitao R, Nagata T, Takeda S, Komaki H, Segawa K, Takenaka K, Komuro I. Prognostic Impact of Venous Thromboembolism in Patients with Duchenne Muscular Dystrophy: Prospective Multicenter 5-Year Cohort Study. Int J Cardiol, in press.

Fukuda N, Itatani K, Kimura K, Ebihara A, Negishi K, Uno K, Miyaji K, Kurabayashi M, Takenaka K. An Inefficient Vortex Remains during the Ejection Period in the Left Ventricle with a Low Ejection Fraction: A Study by Vector Flow Mapping. J Med Ultrasonics 2014 In Press.

Yuan LJ, Takenaka K, Uno K, Ebihara A, Sasaki K, Komuro T, Sonoda M, Nagai R. Normal and shear strains of the left ventricle in healthy human subjects measured by two-dimensional speckle tracking echocardiography. Cardiovasc Ultrasound. 2014;12(1):7.

Takata M, Amiya E, Watanabe M, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Uno K, Saito A, Murasawa T, Ono M, Nagai R, Komuro I. Brachial artery diameter has a predictive value in the improvement of flow-mediated dilation after aortic valve replacement for aortic stenosis. Heart Vessels. 2014 Feb 5. [Epub ahead of print]

Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Shimada Y, Kuroki T, Miyamoto N, Daimon D, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T . Rationale and design of EPISTEME trial: Efficacy of post- stroke intensive rosuvastatin treatment for aortogenic embolic stroke. Cardiovasc Drugs Ther 2014;28(1):79-85.

Chiang SJ, Daimon M, Ishii K, Kawata T, Miyazaki S ,Hirose K, Ichikawa R, Miyauchi K, Yeh MH, Chang NC, Daida H. Assessment of Elevated Levels and Rapid Changes of Left Ventricular Filling Pressure Using a Novel Global Strain Imaging Diastolic Index. Circ J 2014; 78(2):419-27.

Lee S, Daimon M, Kawata T, Kohro T, Kimura K, Nakao T, Koide D, Watanabe M, Yamazaki T, Komuro I. Estimation of Right Atrial Pressure by Inferior Vena Cava Ultrasound in an Asian Population. Circ J, 2014 ;78(4):962-6.

Doughty RN, Gardin JM, Hobbs FD, McMurray JJ, Nagueh SF, Poppe KK, Senior R, Thomas L, Whalley GA, Aune E, Brown A, Badano LP,Cameron V, Chadha DS, Chahal N, Chien KL, Daimon M, et al. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study. Eur Heart J Cardiovasc Imaging. 2014;15(3):341-8.

Maruyama M, Daimon M, Kawata T, Kasai T, Ichikawa R, Miyazaki S, Ohmura H, Yamamoto T, Amano A, DaidaH. Early Hemodynamic Performance of the Trifecta Bioprostheic Valve in Patients with Aortic Valve Disease: An Initial Single-center Experience in Japan. Circ J. in press

Sasaki S, Daimon M, Kawata1 T, Miyazaki S, Ichikawa R, Maruyama M, Chiang SJ, Mahara K, Watanabe H, Sumiyoshi T, Tomoike H, Daida1 H. Factors Responsible for Elevated Plasma B-type Natriuretic Peptide Levels in Severe Aortic Stenosis: Comparison between Elderly and Younger Patients. J Cardiol. In press.

Nishizaki Y, Daimon M, Miyazaki S, Suzuki H, Kawata T, Miyauchi K, Chiang SJ, Makinae H, Shinozaki T, and Daida H. Clinical Factors Associated with Classical Symptoms of Aortic Valve Stenosis. J Heart Valve Dis 2013 ;22(3):287-94.

Ichikawa R, Daimon M, Miyazaki T, Kawata T, Miyazaki S, Maruyama M, Chiang SJ, Suzuki H, Ito C, Sato F, Watada H, Daida H. Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2013 ;12:38.

Yang B, Daimon M, Ishii K, Kawata T, Miyazaki S, Hirose K, Ichikawa R, Chiang SJ, Suzuki H, Miyauchi K, Daida H. Prediction of Coronary Artery Stenosis at Rest in Patients with Normal Left Ventricular Wall Motion: Segmental Analyses Using Strain Imaging Diastolic Index. Int Heart J 2013; 54; 266-272

Chen MJ, Chen KY, Chiang SJ, Daimon M, Lee SJ. The Telehealth Care Service Model of Hypertensive Treatmen. J Telemed Telecare 2013 Jul;19(5):238-41

Makinae H, Numata N, Kitaoka H, Daimon M, Yamamoto T, Amano A. Use of pacemaker programmers for disaster victim identification. Forensic Sci Med Pathol 2013; 9(4):551-3

Kawata T, Daimon M, Hasegawa R, Toyoda T, Sekine S, Himi T, Uchida D, Miyazaki S, Hirose K, Ichikawa R, Maruyama M, Suzuki H and Daida H. Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease. Cardiovasc Diabetol 2013:12(1):121.

Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I.  Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy - Prospective multicenter cohort study. Int J Cardiol. 2013 168:1900-4.

Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I. Melatonin ameliorates angiotensin II-induced vascular endothelial damage via its antioxidative properties. J Pineal Res. 2013;55(3):287-93

Fukuda S, Watanabe H, Daimon M, Abe Y, Hirashiki A, Hirata K, Ito H, Iwai-Takano M, Iwakura K, Izumi C, Hidaka T, Yuasa T, Murata K, Nakatani S, Negishi K, Nishigami K, Nishikage T, Ota T, Hayashida A, Sakata K, Tanaka N, Yamada S, Yamamoto K, Yoshikawa J. Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population. Circ J 2012; 76(5):1177-81.

Chiang SJ, Daimon M, Ishii K, Miyazaki S, Koiso Y, Suzuki H, Miyauchi K, Bei Y, Yeh MH, Hwang B, Daida H. A novel global strain diastolic index correlates with plasma NT-proBNP levels in asymptomatic hypertensive patients with preserved left ventricular ejection fraction. J Echocardiogr 2012; 10: 56-64.

Kimura K, Takenaka K, Ebihara A, Okano T, Uno K, Fukuda N, Ando J, Fujita H, Morita H, Yatomi Y, Nagai R.  Speckle tracking global strain rate E/E' predicts LV filling pressure more accurately than traditional tissue Doppler E/E'.  Echocardiography. 2012 ;29:404-10.

Nakao T, Watanabe H, Takeda N, Takanashi S, Nagai R. The efficacy of real-time three-dimensional transoesophageal echocardiography in detecting unicuspid aortic valve. Eur Heart J Cardiovasc Imaging. 2012 Nov;13(11):966.

Miyazaki S, Daimon M, Miyazaki T, Onishi Y, Koiso Y, Nishizaki Y, Ichikawa R, Chiang SJ, Makinae H, Suzuki H, Daida H, Global Longitudinal Strain in Relation to the Severity of Aortic Stenosis: A Two-dimensional Speckle-tracking Study. Echocardiography 2011; 28: 703-708.

Daimon M, Watanabe H, Abe Y, Hirata K, Hozumi T, Ishii K, Ito H, Iwakura K, Izumi C Matsuzaki M, Minagoe S, Abe H, Murata K, Nakatani S, Negishi K, Yoshida K, Tanabe K, Tanaka N, Tokai K, Yoshikawa J. Gender Differences in Age-related Changes in Left and Right Ventricular Geometries and Functions. An Echocardiographic Study in a Healthy Population. Circ J 2011; 75: 2840-2846.

Kimura K, Takenaka K, Ebihara A, Uno K, Iwata H, Sata M, Kohro T, Morita H, Yatomi Y, Nagai R.  Reproducibility and diagnostic accuracy of three-layer speckle tracking echocardiography in a swine chronic ischemia model.  Echocardiography. 2011 ;28:1148-55.

Kimura K, Takenaka K, Pan X, Ebihara A, Uno K, Fukuda N, Kohro T, Morita H, Yatomi Y, Nagai R. Prediction of coronary artery stenosis using strain imaging diastolic index at rest in patients with preserved ejection fraction. J Cardiol 2011;57:311-5.

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